Tissue engineering is a biomedical field that focuses on the development and production of synthetic structures designed to replace diseased or lost living tissues and organs in the human body. These structures are created by seeding cells and other biological entities into biodegradable or removable three-dimensional media.
As the number of older people increases globally and advanced medical care procedures become available in developing countries, so does the demand for tissues and organs for transplantation. Today, the demand for organs exceeds supply to the point of becoming a social problem resulting in longer wait times for surgery. Tissue engineering is a growing field of science that aims to replace organ transplantation. Therefore, tissue engineering is gaining widespread interest as a method of repairing, reconstructing and replacing tissues and organs.
Synthetic tissues that have simple geometry and do not require blood vessels are already being produced, but the main challenges exist in creating the thick (200 microns or more) and three-dimensional (3D) tissues needed for complex organs such as the heart. , liver and a kidney. These tissues require vascularization, that is to say a network of vessels comprising arteries and arterioles as well as veins and venules. The function of arteries and arterioles is to supply nutrients, growth factors and oxygen to cells, while veins and venules remove metabolic wastes.
Blood supply is necessary for cells to grow, multiply, and form the extracellular matrix (ECM), resulting in the creation of larger tissue constructs and a miniature simplified version of organs called organoids. The extracellular matrix is the material surrounding the cell. It occupies the space between cells and has a network structure made up of proteins (for example, collagen and elastin) and polysaccharides (hyaluronic acid). ECM is the main component of the cellular microenvironment, a dynamic and complex medium with chemical, physical and mechanical properties characteristic of specific tissue. ECM supports cell life, regulates cell behavior, and affects cell-to-cell interaction, cell morphology, and tissue performance.
The report includes:
– An overview of artificial vascularity and micro-environmental factors supporting tissue engineering and organoids
– Estimation of current market size and future demand for 3D printing and tissue engineering products, and market share analysis on the basis of application and geographic region
– Highlights of emerging trends and new technological developments related to artificial vascularization
– Review of existing application areas for artificial vascularization and review of emerging applications
– Assessment of techniques used to produce an artificial vascular system, including materials and processes, with reference to various types of structures such as synthetic tissues, organoids and organs on a chip
Chapter 1 Technology Highlights and Market Outlook
Tissue engineering and vascularization
Current and emerging applications of artificial vascularization
Methods for creating artificial vascularity
3D printing and bioprinting
Emerging trends and latest developments related to artificial vascularization
Powder-based 3D printing
Advanced imaging technologies
Artificial Vascularization Market Outlook
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